TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p
نویسندگان
چکیده
منابع مشابه
Assessment of TGIF as a candidate gene for myopia.
PURPOSE Transforming growth beta-induced factor (TGIF) has been identified as a candidate gene for high myopia through genetic linkage studies and through its role in ocular growth in animal studies. However, the association of single nucleotide polymorphisms (SNPs), based solely on myopia refraction, has so far been inconclusive. This is the first study conducted to investigate the association...
متن کاملThe ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome.
Although X chromosome transfer experiments indicated that tumor suppressor genes are present on the X chromosome, they have not been previously identified. In this report, we show that the ETS transcription factor MEF (ELF4), which is located on chromosome Xq26.1, possesses tumor suppressive capability. MEF expression was up-regulated by 5-azacytidine in some cancer cell lines. MEF overexpressi...
متن کاملSuppressor Gene on the X Chromosome The ETS Transcription Factor MEF Is a Candidate Tumor
Although X chromosome transfer experiments indicated that tumor suppressor genes are present on the X chromosome, they have not been previously identified. In this report, we show that the ETS transcription factor MEF (ELF4), which is located on chromosome Xq26.1, possesses tumor suppressive capability. MEF expression was up-regulated by 5-azacytidine in some cancer cell lines. MEF overexpressi...
متن کاملThe FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.
The JC12 monoclonal antibody recognizes a previously unknown nuclear protein that showed a restricted distribution in normal tonsil and was also overexpressed in a subset of diffuse large B-cell lymphomas. Using this reagent, we expression cloned cDNAs encoding its antigenic target and identified this protein as a novel putative transcription factor, FOXP1. The FOXP1 protein sequence contains p...
متن کاملA Transforming Growth Factor b (TGFb) Control Element Drives TGFb-induced Stimulation of Smooth Muscle a-Actin Gene Expression in Concert with Two CArG Elements*
The goal of the present study was to determine the molecular mechanism whereby transforming growth factor b (TGFb) increases smooth muscle (SM) a-actin expression. Confluent, growth-arrested rat aortic smooth muscle cells (SMC) were transiently transfected with various SM a-actin promoter/chloramphenicol acetyltransferase deletion mutants and stimulated with TGFb (2.5 ng/ml). Results demonstrat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2007
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001997